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  "Package": "GFisher",
  "Type": "Package",
  "Title": "Generalized Fisher's Combination Tests Under Dependence",
  "Version": "0.3.1",
  "Date": "2026-09-02",
  "Authors@R": "c(\nperson(\"Hong\", \"Zhang\", email = \"consistencyzhang@gmail.com\", role = \"aut\"),\nperson(\"Zheyang\", \"Wu\", email = \"zheyangwu@wpi.edu\", role = c(\"aut\", \"cre\"))\n)",
  "Description": "This R package provides accurate and computationally\nefficient methods for computing p-values for a general family\nof Fisher-type statistics (GFisher), including Fisher's\ncombination, Good's statistic, and Lancaster's statistic. It\nsupports flexible weighting schemes and an omnibus procedure\nthat adapts the weights and degrees of freedom to the data. The\npackage includes p-value calculation methods based on\nmoment-ratio matching and joint distribution approximations. It\noffers both pure R implementations and optimized C++ code via\nRcppArmadillo for improved performance on large-scale data. For\nfast calculations under independence, the optional 'coga'\npackage is required for functions with the '_ind' suffix.",
  "URL": "https://zwulab.github.io/GFisher/,\nhttps://github.com/ZWuLab/GFisher,\nhttps://doi.org/10.1111/biom.13634",
  "BugReports": "https://github.com/ZWuLab/GFisher/issues",
  "License": "GPL-3",
  "Encoding": "UTF-8",
  "VignetteBuilder": "knitr",
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  "Repository": "https://zwulab.r-universe.dev",
  "Date/Publication": "2026-09-02 21:30:17 UTC",
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  "NeedsCompilation": "yes",
  "Packaged": {
    "Date": "2026-10-10 13:50:04 UTC",
    "User": "root"
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  "Author": "Hong Zhang [aut],\nZheyang Wu [aut, cre]",
  "Maintainer": "Zheyang Wu <zheyangwu@wpi.edu>",
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    "description": "I am a professor in Mathematical Sciences (biostatistics), Bioinformatics and Computational Biology, and Data Science at WPI. ",
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  "_selfowned": true,
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      "n": 1
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      "n": 1
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      "date": "2026-06-15"
    },
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      "date": "2026-09-02"
    }
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    "openblas",
    "cpp"
  ],
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      "count": 2,
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  "_pkgdown": "https://zwulab.github.io/GFisher/",
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  "_assets": [
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    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
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  "_realowner": "zwulab",
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      "date": "2021-01-22"
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      "date": "2022-03-02"
    },
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      "date": "2026-08-24"
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    "check_coga",
    "clear_GFisher_cache",
    "get_GFisher_cache_size",
    "get_GFisher_cache_stats",
    "getGFishercoef_cached_cpp",
    "getGFishercoef_cpp",
    "getGFisherGM_cached_cpp",
    "getGFisherGM_cpp",
    "getGFisherlam_cpp",
    "p_GFisher_MR_cpp",
    "p.GFisher",
    "p.GFisher_ind",
    "p.GFisher_ind_w1",
    "pval.oGFisher",
    "pval.oGFisher_ind",
    "stat.GFisher",
    "stat.oGFisher",
    "stat.oGFisher_ind"
  ],
  "_help": [
    {
      "page": "check_coga",
      "title": "Check and Install coga Package for Independent Functions",
      "topics": [
        "check_coga"
      ]
    },
    {
      "page": "clear_GFisher_cache",
      "title": "Clear GFisher Coefficient Cache",
      "topics": [
        "clear_GFisher_cache"
      ]
    },
    {
      "page": "get_GFisher_cache_size",
      "title": "Get GFisher Coefficient Cache Size",
      "topics": [
        "get_GFisher_cache_size"
      ]
    },
    {
      "page": "get_GFisher_cache_stats",
      "title": "Get GFisher Cache Statistics",
      "topics": [
        "get_GFisher_cache_stats"
      ]
    },
    {
      "page": "getGFishercoef_cached_cpp",
      "title": "Cached Compute Hermite Polynomial Coefficients for GFisher",
      "topics": [
        "getGFishercoef_cached_cpp"
      ]
    },
    {
      "page": "p.GFisher",
      "title": "GFisher Test P-Value Calculation",
      "topics": [
        "p.GFisher"
      ]
    },
    {
      "page": "p.GFisher_ind",
      "title": "GFisher P-Value for Independent Inputs",
      "topics": [
        "p.GFisher_ind"
      ]
    },
    {
      "page": "p.GFisher_ind_w1",
      "title": "GFisher P-Value for Independent Inputs with Equal Weights",
      "topics": [
        "p.GFisher_ind_w1"
      ]
    },
    {
      "page": "pval.oGFisher",
      "title": "Omnibus GFisher (oGFisher) Test P-Value",
      "topics": [
        "pval.oGFisher"
      ]
    },
    {
      "page": "pval.oGFisher_ind",
      "title": "oGFisher P-Value for Independent Inputs",
      "topics": [
        "pval.oGFisher_ind"
      ]
    },
    {
      "page": "stat.GFisher",
      "title": "GFisher Test Statistic",
      "topics": [
        "stat.GFisher"
      ]
    },
    {
      "page": "stat.oGFisher",
      "title": "Omnibus GFisher (oGFisher) Test Statistics",
      "topics": [
        "stat.oGFisher"
      ]
    },
    {
      "page": "stat.oGFisher_ind",
      "title": "oGFisher Statistics for Independent Inputs",
      "topics": [
        "stat.oGFisher_ind"
      ]
    }
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    "mvtnorm",
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      "title": "Introduction to GFisher",
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        "Overview",
        "Key Features",
        "Basic GFisher Test",
        "Important Note on Weight Normalization",
        "Example 1: Standard Fisher's Method",
        "Example 2: Varying Degrees of Freedom",
        "Example 3: Weighted Combination",
        "Accounting for Dependence",
        "Example 4: Correlated Test Statistics",
        "Comparison of Methods",
        "Example 5: Method Comparison",
        "Omnibus GFisher Test (oGFisher)",
        "Example 6: oGFisher with Multiple Configurations",
        "Example 7: oGFisher P-Value",
        "Genetic Association Example",
        "Example 8: Gene-Based Rare Variant Test",
        "Performance: R vs C++",
        "Summary",
        "References"
      ],
      "created": "2026-06-19 19:54:13",
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